ࡱ> TVSU"-bjbjnn"4:aa xxxxx$<40(4*4*4*4*4*4*4$58VN4!xN4xxo4:xx(4(46/z2`Ѝ&044040888z2z28x 3N4N448` >:">40B>: !2 4> B5=45@=>W 4>:C<5=B0FVW "%' !&$&/ (=D>@<0FVO ?@> =5>1EV4=V B5E=VG=V, O:VA=V B0 :V;L:VA=V E0@0:B5@8AB8:8 ?@54<5B0 70:C?V2;V) =0 70:C?V2;N: $0@<0F52B8G=0 ?@>4C:FVO ( :>4  021:2015 48=89 70:C?V25;L=89 A;>2=8: 33652100-6 =B8=5>?;0AB8G=V 70A>18) (: Abiraterone) 030;L=V 28<>38: #G0A=8:8 ?@>F54C@8 70:C?V2;V ?>28==V =040B8 2 A:;04V B5=45@=>W ?@>?>78FV9 4>:C<5=B8, O:V ?V4B25@46CNBL 2V4?>2V4=VABL B5=45@=>W ?@>?>78FVW CG0A=8:0 B5E=VG=8<, O:VA=8<, :V;L:VA=8< B0 V=H8< 28<>30< 4> ?@54<5B0 70:C?V2;V, 2AB0=>2;5=8< 70<>2=8:><: >?VO ;VF5=7VW =0 ?@02> B>@3V2;V ;V:0@AL:8<8 70A>10<8, 2840=>W 5@602=>N A;C61>N #:@0W=8 7 ;V:0@AL:8E 70A>1V2 C ?0?5@>2V9 D>@<V 01> V=D>@<0FVN 7 >DVFV9=>3> 5TAB@C <VAFL ?@>20465==O 4VO;L=>ABV 7 >?B>2>W B0 @>74@V1=>W B>@3V2;V ;V:0@AL:8<8 70A>10<8 7 ?>A8;0==O< =0 2V4?>2V4=C AB>@V=:C 251-?>@B0;C. >2V4:0 2 4>2V;L=V9 D>@<V ?@> 30@0=BVW =0O2=>ABV A5@B8DV:0BV2 O:>ABV B0 @5TAB@0FV9=8E ?>A2V4G5=L =0 B>20@. >2V4:0, 2 O:V9 CG0A=8: B>@3V2 707=0G0T 45B0;L=89 >?8A B>20@C 70 =0ABC?=8< 27V@F5<: ! ?/?0720 B>20@C8@>1=8:, :@0W=0 ?>E>465==O 5TAB@0FV9=5 ?>A2V4G5==O (!) >2V4:0 2 4>2V;L=V9 D>@<V, O:0 <VAB8BL V=D>@<0FVN ?@> 70;8H:>289 B5@<V= ?@840B=>ABV B>20@C, O:89 ?>28=5= AB0=>28B8 =0 45=L ?>AB02:8 =5 <5=H5 50% 2V4 7030;L=>3> B5@<V=C ?@840B=>ABV 01> =5 <5=H5 6 <VAOFV2 4> 70:V=G5==O B5@<V=C ?@840B=>ABV. >2V4:0 2 4>2V;L=V9 D>@<V, O:0 <VAB8BL V=D>@<0FVN ?@> <>6;82VABL 74V9A=5==O ?>AB02:8 ;V:0@AL:8E 70A>1V2 =5 ?V7=VH5 O: ?@>BO3>< 5 (? OBL) @>1>G8E 4=V2 7 <><5=BC ?8AL<>2>3> 70<>2;5==O B>20@C.  <5B>N 70?>1V30==O 70:C?V2;V D0;LA8DV:0BV2 ;V:0@AL:8E 70A>1V2 B0 >B@8<0==O 30@0=BV9 =0 A2>TG0A=5 ?>AB0G0==O B>20@C C =5>1EV4=V9 :V;L:>ABV B0 O:>ABV, #G0A=8: ?>28=5= =040B8 >@83V=0; 30@0=BV9=>3> ;8AB0 2V4 B>20@>LNz0 L L n f h j D .X8:ǴvncXPXPHPv@vnho$fB*phh6B*phhflB*phhflhflB*phh9hB*phhkaB*phh9hkaB*phh:hka5B*ph*hVnhVn5>*CJOJQJaJnHtHhkaCJOJQJaJnHtH$hhkaCJOJQJaJnHtH'h9hka5CJOJQJaJnHtH$h@3hkaCJOJQJaJnHtH!hka5CJOJQJaJnHtHLNz0 L L n h j :<$ & F[$\$^`a$gd$[$\$`a$gd$[$\$`a$gdVn $\$a$gdVn$d`a$gdVn$d`a$gdka$d`a$gdka:<F@Z\rt2 N#P#j'l'x'4(8(:(d)f))ǿǴǤǤҔwlwlwaVhlThkaB*phhhlTB*phhhqB*phhhkaB*phhhB*ph h\Uhh\hKnB*phhpUB*phh!B*phh!h!B*phhKB*phh9hkaB*ph h9hkah9hkaCJOJQJaJhkaCJOJQJaJh9ho$fB*ph<HbI6$[$\$`a$gdkd$$Ifl\&S; t0/'644 layto$f$$If`a$gd2P#`&l'f)>+@++qbT$d*$a$gdka$[$\$a$gdo$f$ & F [$\$^ `a$gd*$ & F [$\$^ `a$gd$ [$\$^ `a$gd$[$`a$gdm$$ & F[$^`a$gdm$$ & F[$\$^`a$gd 28@>1=8:0 01> ?@54AB02=8FB20 (DV;VW) V=>75<=>3> B>20@>28@>1=8:0 2 #:@0W=V, 01> ?@54AB02=8:0 B>20@>28@>1=8:0 2 #:@0W=V: 48;5@0, 48AB@81 NB>@0 B0 V=. (C @07V O:I> B>20@ =5 28@>1;OTBLAO =0 B5@8B>@VW #:@0W=8), O:8< ?V4B25@46CNBLAO <>6;82VABL ?>AB02:8 B>20@C, O:89 T ?@54<5B>< 70:C?V2;V F8E B>@3V2 C :V;L:>ABV, 7V AB@>:0<8 ?@840B=>ABV B0 2 B5@<V= ?>AB02:8, 287=0G5=V FVTN B5=45@=>N 4>:C<5=B0FVTN B0 ?@>?>78FVTN CG0A=8:0 B>@3V2. /:I> 30@0=BV9=89 ;8AB =040TBLAO CG0A=8:C 2V4 V<5=V ?@54AB02=8FB20 (DV;VW) V=>75<=>3> B>20@>28@>1=8:0 2 #:@0W=V, 01> ?@54AB02=8:0 B>20@>28@>1=8:0 2 #:@0W=V (48;5@0, 48AB@81 NB>@0 B0 V=.) CG0A=8: ?>28=5= =040B8 :>?VW 4>:C<5=BV2, O:V ?V4B25@46CNBL ?@02>2V4=>A8=8 ?@54AB02=8FB20/?@54AB02=8:0 7 B>20@>28@>1=8:>< (>DVFV9=89 ;8AB B>20@>28@>1=8:0, :>?VO 48;5@AL:>W G8 48AB@81 NB>@AL:>W C3>48 B>I>). 0@0=BV9=89 ;8AB ?>28=5= 2:;NG0B8: =072C 70<>2=8:0, CG0A=8:0, =072C ?@54<5BC 70:C?V2;V 73V4=> >3>;>H5==O, =><5@ 70:C?V2;V C A8AB5<V.  @07V ?>40GV 5:2V20;5=BC B>20@C, I> 2:070=89 C <548:>-B5E=VG=8E 28<>30E FVTW B5E=VG=>W A?5F8DV:0FVW, #G0A=8: ?>40T ?>@V2=O;L=C E0@0:B5@8AB8:C 70?@>?>=>20=>3> =8< B>20@C B0 B>20@C, I> 287=0G5=0 2 " 7 2V4><>ABO<8 I>4> 2V4?>2V4=>ABV 28<>30< 0<>2=8:0. V4?8A0=0 CG0A=8:>< "5E=VG=0 A?5F8DV:0FVO (@>74V; 548:>-B5E=VG=V 28<>38 B0 >1AO3 70:C?V2;V 70 ;>B><*, 70 ;>B>< =0 O:89 ?>40TBLAO B5=45@=0 ?@>?>78FVO) 2 B01;8FV 70 D>@<>N, O:0 =02545=0 C 2V4?>2V4=><C ;>BV 40=>W B5E=VG=>W A?5F8DV:0FVW. 548:>-B5E=VG=V 28<>38 B0 >1AO3 70:C?V2;V 70 ;>B><* $>@<0 28?CA:C B0 4>7C20==O48=8FO 28<V@CV;L:VABLAbirateroneB01;5B:8, 2:@8BV ?;V2:>2>N >1>;>=:>N, ?> 500 <3"01;5B:86 000*2AV ?>A8;0==O =0 B>@3>25;L=C <0@:C, DV@<C, ?0B5=B, :>=AB@C:FVN 01> B8? ?@54<5B0 70:C?V2;V, 465@5;> 9>3> ?>E>465==O 01> 28@>1=8:0 A;V4 G8B0B8 O: 01> 5:2V20;5=B. )0*>+@+++++,,2,4,,,,Ǵǟp]J7'hB*OJQJnH"phtH"%h>Fh>FB*OJQJnH"phtH"%hhB*OJQJnH"phtH"%hVnh>FB*OJQJnH"phtH"*hVnhVn5>*CJOJQJaJnHtHhhoQhOJQJhhoQh5OJQJ\)hU1hd<56B*CJ\]aJph%hm.5CJOJPJQJaJnHtH+hhka5CJOJPJQJaJnHtHh@3hkaB*phhlThkaB*phhlThka6B*ph++++,, $$Ifa$gdka$[$\$a$gdka,,4,,B1#d$Ifgd$d$Ifa$gdHkd$$Ifl,\ ~ &f fk ff t0/'44 lBap(yt>F,,,$d$Ifa$gdHd$Ifgd>F,,,--ͽhuOth76CJOJQJaJhuOthm.6CJOJQJaJho$fh>FB*OJQJph%h>Fh>FB*OJQJnH"phtH",,-*(kd$$Ifl\ ~ && &k &&  t(0/'44 lap(yt>F21h:pka. A!n"Q#o$S% $$If!vh#vS#v#v;#v :V l t0/'6,5S55;5 yto$f$$If!vh#v #vk #v#v:V l, t0/'5 5k 559Bp(yt>F$$If!vh#v #vk #v#v:V l  t(0/'5 5k 559/ p(yt>F s666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662&6FVfv2(&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ OJPJQJ_HmH"nH"sH"tH"P`P  28G09=89 dCJ_HaJmH"sH"tH PA P (@8DB 0170FC 70 ?@><>2G0==O<Zi@Z 028G09=0 B01;8FO4 l4a 2k 2 0 5<0T A?8A:C f^@f ka028G09=89 (251)ddd[$\$CJOJPJQJaJtH"|| ka !VB:0 B01;8FV7:V0 CJaJtH LL /`D05@E=V9 :>;>=B8BC;  E$R/!R /`D05@E=V9 :>;>=B8BC; =0: CJaJtH PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭VhR*Պ"(Ͽ{ߟ?qN&dsK= ĂˁM;^}^|ݲh!ra1;u(~h%ϝ-̈Cl52nE͙LwI=jܿP{^-h4\t~VzZ6/?^R ^Rz% ^jwWxw]k`2a~9_SLX,fI J #3JLA^>{vp_<8S6re]DT/ytu<~o=xzWCvvtD;WsE@ b"[)G1XDh,E\q؀ ƒ0 bx) 6ck.ɹ0>y2qڳro>%6A ( Gv1!F\(aMs8D!VFIyYBlt:V{& D-䇘aE6CQ=m$dz\@27Ɯl&^-@fiߦD&|^F. BlC߅E5&lmf!;Ň&FV:U_%03w@ 0t=""&' /~lYHݱcy;!ֻ⚄[%cvknNɶ>tmkaW5 t _jϡ/0(-,Οf!\{0p)'a#"Af/ɔgܙ15l-tmqZ.GT>8񒟏HѵQ,wNC󒀴= m2DBAR4 SaѴhHTmjyV`v ::),- <+,,,- 8@0(  B S  ?$  ? @  %'<=%&6A35\]#$01LMilYZ    5 6 > ? D F  7 [&if "~I\![&i$"~];"~Vm@㦖j^2A"~>OHf¸W|KI"~&Q[&i6{iv[&ih ^`hH.h ^`hH.h pL^p`LhH.h @ ^@ `hH.h ^`hH.h L^`LhH.h ^`hH.h ^`hH.h PL^P`LhH.h^h`.8^8`.L^`L. ^ `. ^ `.xL^x`L.H^H`.^`.L^`L.h ^`hH.h ^`hH.h pL^p`LhH.h @ ^@ `hH.h ^`hH.h L^`LhH.h ^`hH.h ^`hH.h PL^P`LhH.h^h`.8^8`.L^`L. ^ `. ^ `.xL^x`L.H^H`.^`.L^`L.h^h`.8^8`.L^`L. ^ `. ^ `.xL^x`L.H^H`.^`.L^`L.^`o()^`.pL^p`L.@ ^@ `.^`.L^`L.^`.^`.PL^P`L.h^h`.8^8`.L^`L. ^ `. ^ `.xL^x`L.H^H`.^`.L^`L.h ^`hH.h ^`hH.h pL^p`LhH.h @ ^@ `hH.h ^`hH.h L^`LhH.h ^`hH.h ^`hH.h PL^P`LhH.h^h`.8^8`.L^`L. ^ `. ^ `.xL^x`L.H^H`.^`.L^`L.h ^`hH.h ^`hH.h pL^p`LhH.h @ ^@ `hH.h ^`hH.h L^`LhH.h ^`hH.h ^`hH.h PL^P`LhH.h ^`hH.h ^`hH.h pL^p`LhH.h @ ^@ `hH.h ^`hH.h L^`LhH.h ^`hH.h ^`hH.h PL^P`LhH. Vm@$f W|KI];j^2A>OHI\!6{iv7 &Q """""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""* u  I \(Mc93@e_HBm9sx<;Hfl7b}!!0#m./`D>F`FHKlTuTpUi[c`o$foQhInKnZruOtaw.x.xpz:k6p]DVj@[fZs[*6H9\Vn4kad<WOq~mN/ @ @ @ @ @   UnknownG.[x Times New Roman5Symbol3. .[x Arial7..{$ CalibriA$BCambria Math"qG{    !nor0  KqHP  $Pka2!xx  Andriy Mykh Andriy Mykh8         Oh+'0t  0 < HT\dl Andriy Mykh Normal.dotm Andriy Mykh26Microsoft Office Word@.@@`e@fys&  ՜.+,0 hp|         !"#$%'()*+,-./0123456789:;<=>?@ABDEFGHIJLMNOPQRURoot Entry FȚ&WData 1Table&)9WordDocument4:SummaryInformation(CDocumentSummaryInformation8KCompObjr  F Microsoft Word 97-2003 MSWordDocWord.Document.89q